DPMA Calculation for Item 7250N Dosage 1555

Steps 1 and 2

Vector R= [0.038198 0.0382 0.1034 0.10342 1.09]

Matrix S =

5000

1000

50

500

5

Steps 3 and 4

The algorithm considers the following vial combinations:

0 vials of size 5000
1. Stage 4, candidate price 1 (This number of vials overfills the dosage) rejected due to not enough content
2. Stage 4, candidate price 2 (Use smaller sizes of the cheapest vial) rejected due to no smaller vial sizes
3. Stage 4, candidate price 3 (Use more expensive vials)
  - 0 vials of size 1000 rejected due to non-zero balance and no more vials to consider
  - 1 vial of size 1000 rejected due to non-zero balance and no more vials to consider
  - 0 vials of size 1000
    
    Stage 4, candidate price 1 (This number of vials overfills the dosage) rejected due to not enough content
    
    Stage 4, candidate price 2 (Use smaller sizes of the cheapest vial) rejected due to no smaller vial sizes
    
    Stage 4, candidate price 3 (Use more expensive vials) rejected due to More expensive vials can't be cheaper than overfilling with cheaper vials
  - 1 vial of size 1000
    
    Stage 4, candidate price 1 (This number of vials overfills the dosage) rejected due to not enough content
    
    Stage 4, candidate price 2 (Use smaller sizes of the cheapest vial) rejected due to no smaller vial sizes
    
    Stage 4, candidate price 3 (Use more expensive vials) rejected due to More expensive vials can't be cheaper than overfilling with cheaper vials
  - 2 vials of size 1000
    
    Stage 4, candidate price 1 (This number of vials overfills the dosage) is a candidate DPMA of 76.4
    
    Stage 4, candidate price 2 (Use smaller sizes of the cheapest vial) rejected due to no smaller vial sizes
    
    Stage 4, candidate price 3 (Use more expensive vials) rejected due to no dosage and/or no vials
1 vial of size 5000
1. Stage 4, candidate price 1 (This number of vials overfills the dosage) is a candidate DPMA of 190.99
2. Stage 4, candidate price 2 (Use smaller sizes of the cheapest vial) rejected due to no smaller vial sizes
3. Stage 4, candidate price 3 (Use more expensive vials) rejected due to no dosage and/or no vials

Most Cost-Efficient Vial Combination

The lowest priced vial combination is:

DPMA = 76.4. Consisting of the following vials:

2 vials of content 1000 from available brands PF, EA, PF, OD
0 vials of content 5000 from available brand SZ

More expensive vial combinations considered are:

DPMA = 190.99. Consisting of the following vials:

1 vial of content 5000 from available brand SZ